Alemán Publications


The effects of trans-resveratrol on insulin resistance, inflammation, and microbiota in men with the metabolic syndrome: A pilot randomized, placebo-controlled clinical trial.

Walker JM, Eckardt P, Aleman JO, da Rosa JC, Liang Y, Iizumi T, Etheve S, Blaser MJ, L Breslow J, Holt PR.

J Clin Transl Res. 2018 Dec 7;4(2):122-135. eCollection 2019 Jan 10.


An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation.

Zhu J, He J, Verano M, Brimmo AT, Glia A, Qasaimeh MA, Chen P, Aleman JO, Chen W.

Lab Chip. 2018 Dec 7;18(23):3550-3560. doi: 10.1039/c8lc00605a. Epub 2018 Oct 10.


Circulating MIR148A associates with sensitivity to adiponectin levels in human metabolic surgery for weight loss

Ariza-Nieto M, Alley JB, Samy S, Fitzgerald L, Vermeylen F, Shuler ML, Alemán JO.

Endocr Connect. 2018 Sep 1;7(9):975-982. doi: 10.1530/EC-18-0205.


The Changing Landscape of Diabetes Therapy for Cardiovascular Risk Reduction: JACC State-of-the-Art Review.

Newman JD, Vani AK, Aleman JO, Weintraub HS, Berger JS, Schwartzbard AZ.

J Am Coll Cardiol. 2018 Oct 9;72(15):1856-1869. doi: 10.1016/j.jacc.2018.07.071. Review.


Fecal microbiota and bile acid interactions with systemic and adipose tissue metabolism in diet-induced weight loss of obese postmenopausal women.

Alemán JO, Bokulich NA, Swann JR, Walker JM, De Rosa JC, Battaglia T, Costabile A, Pechlivanis A, Liang Y, Breslow JL, Blaser MJ, Holt PR.

J Transl Med. 2018 Sep 3;16(1):244. doi: 10.1186/s12967-018-1619-z.


Circulating miR-148a associates with sensitivity to adiponectin levels in human metabolic surgery for weight loss.

Ariza-Nieto M, Alley JB, Samy S, Fitzgerald L, Vermeylen F, Shuler ML, Aleman JO.

Endocr Connect. 2018 Aug 2. pii: EC-18-0205. doi: 10.1530/EC-18-0205. [Epub ahead of print]


Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women.

Alemán JO, Iyengar NM, Walker JM, Milne GL, Da Rosa JC, Liang Y, Giri DD, Zhou XK, Pollak MN, Hudis CA, Breslow JL, Holt PR, Dannenberg AJ.

J Endocr Soc. 2017 Apr 25;1(6):625-637. doi: 10.1210/js.2017-00020. eCollection 2017 Jun 1.


Docosahexaenoic Acid Supplementation is Not Anti-Inflammatory in Adipose Tissue of Healthy Obese Postmenopausal Women.

Holt PR, Alemán JO, Walker JM, Jiang CS, Liang Y, de Rosa JC, Giri DD, Iyengar NM, Milne GL, Hudis CA, Breslow JL.

Int J Nutr. 2017;1(4):31-49. doi: 10.14302/issn.2379-7835.ijn-17-1636. Epub 2017 Jul 21.


Celecoxib does not alter intestinal microbiome in a longitudinal diet-controlled study.

Bokulich NA, Battaglia T, Aleman JO, Walker JM, Blaser MJ, Holt PR.

Clin Microbiol Infect. 2016 May;22(5):464-5. doi: 10.1016/j.cmi.2016.01.013. Epub 2016 Jan 22. No abstract available.


Noninvasive Detection of Inflammatory Changes in White Adipose Tissue by Label-Free Raman Spectroscopy.

Haka AS, Sue E, Zhang C, Bhardwaj P, Sterling J, Carpenter C, Leonard M, Manzoor M, Walker J, Aleman JO, Gareau D, Holt PR, Breslow JL, Zhou XK, Giri D, Morrow M, Iyengar N, Barman I, Hudis CA, Dannenberg AJ.

Anal Chem. 2016 Feb 16;88(4):2140-8. doi: 10.1021/acs.analchem.5b03696. Epub 2016 Jan 28.


Basal Insulin Use in the Non-Critical Care Setting: Is Fasting Hypoglycemia Inevitable or Preventable?

Flory JH, Aleman JO, Furst J, Seley JJ.

J Diabetes Sci Technol. 2014 Mar;8(2):427-428. Epub 2014 Jan 21. No abstract available.


Effects of tyrosine kinase inhibition on bone metabolism: untargeted consequences of targeted therapies.

Alemán JO, Farooki A, Girotra M.

Endocr Relat Cancer. 2014 May 8;21(3):R247-59. doi: 10.1530/ERC-12-0400. Print 2014 Jun. Review.


Mechanisms of obesity-induced gastrointestinal neoplasia.

Alemán JO, Eusebi LH, Ricciardiello L, Patidar K, Sanyal AJ, Holt PR.

Gastroenterology. 2014 Feb;146(2):357-373. doi: 10.1053/j.gastro.2013.11.051. Epub 2013 Dec 6. Review.


Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells.

Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G.

Mol Biosyst. 2011 May;7(5):1409-19. doi: 10.1039/c0mb00309c. Epub 2011 Feb 16.


Ketogenic essential amino acids modulate lipid synthetic pathways and prevent hepatic steatosis in mice.

Noguchi Y, Nishikata N, Shikata N, Kimura Y, Aleman JO, Young JD, Koyama N, Kelleher JK, Takahashi M, Stephanopoulos G.

PLoS One. 2010 Aug 10;5(8):e12057. doi: 10.1371/journal.pone.0012057.


The phosphoinositide 3-kinase regulatory subunit p85alpha can exert tumor suppressor properties through negative regulation of growth factor signaling.

Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Alemán JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR.

Cancer Res. 2010 Jul 1;70(13):5305-15. doi: 10.1158/0008-5472.CAN-09-3399. Epub 2010 Jun 8.


Effect of anaplerotic fluxes and amino acid availability on hepatic lipoapoptosis.

Noguchi Y, Young JD, Aleman JO, Hansen ME, Kelleher JK, Stephanopoulos G.

J Biol Chem. 2009 Nov 27;284(48):33425-36. doi: 10.1074/jbc.M109.049478. Epub 2009 Sep 16.


Hepatic insulin resistance is sufficient to produce dyslipidemia and susceptibility to atherosclerosis.

Biddinger SB, Hernandez-Ono A, Rask-Madsen C, Haas JT, Alemán JO, Suzuki R, Scapa EF, Agarwal C, Carey MC, Stephanopoulos G, Cohen DE, King GL, Ginsberg HN, Kahn CR.

Cell Metab. 2008 Feb;7(2):125-34. doi: 10.1016/j.cmet.2007.11.013.


The p85alpha regulatory subunit of phosphoinositide 3-kinase potentiates c-Jun N-terminal kinase-mediated insulin resistance.

Taniguchi CM, Aleman JO, Ueki K, Luo J, Asano T, Kaneto H, Stephanopoulos G, Cantley LC, Kahn CR.

Mol Cell Biol. 2007 Apr;27(8):2830-40. Epub 2007 Feb 5.